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The antidepressant, stimulant and entactogenic triptamine medication (abbreviated as αMT, AMT, or AMT) Initially developed by Upjohn workers as an antidepressant in the 1960’s, it was used briefly in Russia as an antidepressant under the trade name Indopan before being discontinued.
αMT is tryptamine with an alpha carbon substitution methyl. This alpha substitution causes monoamine oxidase A to be a relatively poor substratum, which prolongs the half-life of αMT, allowing it to reach the brain and enter the central nervous system. The molecular interaction of tryptamine and phenethylamine is similar to the drug, with α-methylphenethylamine being an amphetamine. αMT is closely related to the serotonin neurotransmitter (5-hydroxytryptamines), which partly explains its action mechanism.
The synthesis of αMT may be achieved on several specific paths; the two most commonly recognized are the nitroaldol condensation from the ammonium acetate catalyst to the indole-3 carboxaldehyde and nitroethane and the condensation from the indole-3-acetone to the lithium aluminum hydride, these are preceded by the reduction in ketoxime produced.
αMT acts as an inhibitor and release agent of the main three Monoamines of the relative equilibrium of the reuptake; serotonin, norepinephrine and dopamine and as an agonist of non-selective serotonin receivers.